Benzodiazepines (Valium® and Klonopin®)
Like baclofen, benzodiazepines are a group of drugs that act on the central nervous system to relax muscles, temporarily decreasing spasticity. Diazepam is the most commonly used benzodiazepine in the treatment of spasticity. Because of their sedative effects, benzodiazepines are given most often at night. Additional effects may include low blood pressure, nausea, difficulty thinking clearly, confusion, depression, clumsiness, and trouble with balance, memory impairment, and behavioral problems. Benzodiazepines may be addictive, and, with long-term use, withdrawal symptoms may occur if the drug is stopped too quickly. These drugs should not be taken in combination with alcohol or other central nervous system depressants.