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Anticholinergics have a limited role in PD. They are primarily effective against tremor and rigidity, and their side effects may be significant, especially in elderly patients.
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Anticholinergics

Anticholinergics have a limited role in PD. They are primarily effective against tremor and rigidity, and their side effects may be significant, especially in elderly patients. Typical doses for common anticholinergics are:

  • Trihexyphenidyl (Artane®): 2 to 15 mg/day
  • Benztropine: 1.0 to 4.5 mg/day
  • Ethopropazine: 10 to 200 mg/day

Common side effects are memory loss, dry mouth, urinary retention, constipation, sedation, delirium, and hallucinations.