Amantadine (Symmetrel®) has a mild symptomatic effect on the motor symptoms of PD, but a more significant effect on the reduction of dyskinesias.

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Amantadine

Amantadine (Symmetrel®) has a mild symptomatic effect on the motor symptoms of PD, but a more significant effect on the reduction of dyskinesias. The usual dose is 100 mg 2 to 4 times each day. Side effects include hallucinations, difficulty falling asleep or staying asleep (insomnia), agitation, and difficulty concentrating; dry mouth, ankle swelling, and skin mottling (uneven color tones) may also be present. Amantadine may be ineffective for dyskinesias in up to one-third of patients.